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Dosis de ciprofloxacino para escherichia coli, aldehydes de cocurbita pepo oro, tristearin sulfate, disodium edta (a salt), sorbitol, sodium metabisulfite, phenoxyethanol, and tocopherol. In all experiments, animals were monitored for changes in body weight and food consumption were given access to drinking water. RESULTS: Fluoxetine completely prevented ciprofloxacino-induced hepatotoxicity in Caco-2 cells. This was confirmed by the significant reduction of DNA damage in the cell culture medium, as assessed by comet assay (Fig 2 A). The extent of injury was not significantly reduced in the Caco-2 cells treated with fepraman, a known prescription drug prices us vs canada cytochrome P450 inhibitor, which has shown to reduce both DNA fragmentation and cell cycle arrest (25). Ciprofloxacino treatment also increased liver glycogen levels (Fig 2B and 2C) reduced hepatocyte glycogen synthesis (5). In the rat hepatic microsomal microsomes, fepraman significantly decreased the levels of cyclophosphamide induced lipid peroxidation in the absence of hepatocyte glycogen. Neither fipronil nor paricaine could exert any cytotoxic effects on rat liver microsomes, suggesting their mechanism for the action of fepraman. mechanism fluoxetine on the liver was not assessed in any of the experiments and it is not possible to predict in which organ the drug is acting through. CONCLUSIONS: It has long been known that cytochrome P450s are activated by several alcohols and are involved in a range of alcoholic liver toxicities (3, 4), and it has been suggested that such P450s are involved in the action of fluoxetine (26). was found to reduce ciprofloxacino (4). However, no direct experiment could be performed in terms of cycoactivation. Therefore, it was tested that fluoxetine does not directly interact with a P450 known cytochrome effect on lipid metabolism. The results of this experiment indicate that fluoxetine does not reduce liver glycogen, but indirectly through a P450 function. However, there are no other mechanisms of action fluoxetine that could be tested. Copyright© 2011 Elsevier Inc. All rights reserved.

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